CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles

CoverageAnalyzer (CAn): A Tool for Inspection of Modification Signatures in RNA Sequencing Profiles

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Combination of reverse transcription (RT) and deep sequencing has emerged as a powerful instrument for the detection of RNA modifications, a field that has seen a recent surge in activity because of its importance in gene regulation.Recent studies yielded high-resolution RT signatures of modified ribonucleotides relying on both sequence-dependent mismatch patterns and reverse transcription arrests.Common alignment viewers lack specialized functionality, such as filtering, tailored visualization, image export and differential analysis.Consequently, kiara sky peach sangria the community will profit from a platform seamlessly connecting detailed visual inspection of RT cowboys ps5 controller signatures and automated screening for modification candidates.

CoverageAnalyzer (CAn) was developed in response to the demand for a powerful inspection tool.It is freely available for all three main operating systems.With SAM file format as standard input, CAn is an intuitive and user-friendly tool that is generally applicable to the large community of biomedical users, starting from simple visualization of RNA sequencing (RNA-Seq) data, up to sophisticated modification analysis with significance-based modification candidate calling.